Kleijnen Systematic Reviews (KSR) Ltd has been commissioned to prepare a range of systematic reviews for governmental and other publicly funded bodies, health insurance associations, pharmaceutical companies and organisations that deliver health services.
We aim to make the reports publicly available whenever feasible. We have grouped our projects by our main funders:
Working with a range of commissioners
National Institute for Health Research
Kleijnen Systematic Reviews Ltd is a "Centre of Excellence" for Technology Assessment Reviews (TARs), appointed by the National Institute for Health Research (NIHR).
National Institute for Health Research
Kleijnen Systematic Reviews Ltd is a "Centre of Excellence" for Technology Assessment Reviews (TARs), appointed by the National Institute for Health Research (NIHR).
TARs provide a reliable and rigorous evidence assessment of the benefits, harms and costs of particular healthcare treatments for those who plan, provide or receive care in the NHS.
TARs are commissioned to meet the urgent needs of national NHS decision-making bodies and policy customers, such as the National Institute for Health and Care Excellence (NICE). TARs are most commonly produced to inform NICE Appraisal Committee guidance on the use of new and existing medicines, treatments and procedures within the NHS in England and Wales.
Recently completed projects
- Pembrolizumab for neoadjuvant and adjuvant treatment of triple-negative early or locally advanced breast cancer
- Esketamine nasal spray for treatment-resistant depression
- SeHCAT (tauroselcholic [75 selenium] acid) for diagnosing bile acid diarrhoea
- Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanoma
- Amivantamab for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapy
- Mobocertinib for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapy
Other organisations
Kleijnen Systematic Reviews Ltd works with a wide range of organisations by preparing high-quality evidence syntheses.
Other organisations
Kleijnen Systematic Reviews Ltd works with a wide range of organisations by preparing high-quality evidence syntheses.
Projects are commissioned by organisations such as the Swiss Federal Office of Public Health (FOPH), the University Hospital Schleswig-Holstein (Germany), the Robert Koch-Institute in Germany as well as national and international guideline organisations.
Recently completed projects
- Guideline for the diagnosis and treatment of Faecal Incontinence-A UEG/ESCP/ESNM/ESPCG collaboration
- Role of the faecal immunochemical test in patients with risk-stratified suspected colorectal cancer symptoms: a systematic review and meta-analysis to inform the ACPGBI/BSG guidelines
- A scattered landscape: assessment of the evidence base for 71 patient decision aids developed in a hospital setting
- Duration of Protection After Vaccination Against Yellow Fever: A Systematic Review and Meta-Analysis
- Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)
Medical Industry
Kleijnen Systematic Reviews Ltd works with commissioners from the medical industry to provide support in all things related to evidence-based healthcare.
Medical Industry
Kleijnen Systematic Reviews Ltd works with commissioners from the medical industry to provide support in all things related to evidence-based healthcare.
The exact needs for a project are determined in cooperation with the commissioner. This could include systematic reviews of interventions, diagnostic or prognostic topics, health technology assessments, cost-effectiveness analyses, or information specialist services, e.g. to identify research priorities or to support a submission to a reimbursement agency.
KSR also provides training courses which can be tailored to the exact needs of a commissioner. See here for further details.