KSR staff publications


Ament SM, de Groot JJ, Maessen JM, Dirksen CD, van der Weijden T, Kleijnen J. Sustainability of professionals' adherence to clinical practice guidelines in medical care: a systematic review. BMJ Open 2015;5(12):e008073. Full text.


Westwood M, Ramaekers B, Whiting P, Tomini F, Joore M, Armstrong N, et al. Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis. Health Technol Assess 2015;19(96):1-236. Full text.


Ryder S, Armstrong N, Arjunji R, Peterson S, Riemsma R, Ganguly R, et al. A review of cost effectiveness studies of rheumatoid arthritis (RA) interventions in the UK and US. Poster presented at 18th Annual European Congress of International Society for Pharmacoeconomics and Outcomes Research (ISPOR); 7-11 Nov; Milan, Italy. Value Health 2015;18(7):A644–5. Abstract.


de Groot JJ, Ament SM, Maessen JM, Dejong CH, Kleijnen JM, Slangen BF. Enhanced recovery pathways in abdominal gynecologic surgery: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2015:[Epub ahead of print]. Abstract.


Blommestein HM, Armstrong N, Ryder S, Deshpande S, Worthy G, Noake C, Riemsma R, Kleijnen J, Severens JL, Al MJ. Lenalidomide for the treatment of low- or intermediate-1-risk myelodysplastic syndromes associated with deletion 5q cytogenetic abnormality: an evidence review of the NICE submission from Celgene. PharmacoEcon 2015:[Epub ahead of print]. Full text.


Hussein N, Weng SF, Kai J, Kleijnen J, Qureshi N. Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.  Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD010849. DOI: 10.1002/14651858.CD010849.pub2. Full text.


Schröer-Günther M, Scheibler F, Wolff R, Westwood M, Baumert B, Lange S. PET und PET-CT zur bewertung des ansprechens einer neoadjuvanten therapie beim osophaguskarzinom: eine systematische ubersicht. Dtsch Arztebl 2015;112(33-34):545-52. Full text.


Peinemann F, Kleijnen J. Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study. BMJ Open 2015;5(8):e007540. Full text.


Wolff RF, Ryder S, Bossi A, Briganti A, Crook J, Henry A, Karnes J, Potters L, de Reijke T, Stone N, Burckhardt M, Duffy S, Worthy G, Kleijnen J. A systematic review of randomised controlled trials of radiotherapy for localised prostate cancer. Eur J Cancer. 2015 Aug 5. pii: S0959-8049(15)00699-1. doi: 10.1016/j.ejca.2015.07.019. [Epub ahead of print]. Full text.


Wielders LH, Lambermont VA, Schouten JS, van den Biggelaar FJ, Worthy G, Simons RW, et al. Prevention of cystoid macular edema after cataract surgery in non-diabetic and diabetic patients: a systematic review and meta-analysis. Am J Ophthalmol 2015;pii:S0002-9394(15)00456-0. [Epub ahead of print]. Abstract.


Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess 2015;19(58):1-228. Full text.


Ben-Shlomo Y, Collin SM, Quekett J, Sterne JA, Whiting P. Presentation of diagnostic information to doctors may change their interpretation and clinical management: a web-based randomised controlled trial. PLoS One 2015;10(7):e0128637. Full text.


Westwood M, van Asselt T, Ramaekers B, Whiting P, Thokala P, Joore M, Armstrong N, Ross J, Severens J, Kleijnen J. High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people with acute chest pain: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015 Jun;19(44):1-234. doi: 10.3310/hta19440. Full text.


Whiting P, Savović J, Higgins JP, Caldwell DM, Reeves BC, Shea B, Davies P, Kleijnen J, Churchill R; ROBIS group. ROBIS: A new tool to assess risk of bias in systematic reviews was developed.[Epub ahead of print] Journal of Clinical Epidemiology 2015;pii: S0895-4356(15)00308-X. doi: 10.1016/j.jclinepi.2015.06.005. Full text.


Penny F. Whiting, PhD; Robert F. Wolff, MD; Sohan Deshpande, MSc; Marcello Di Nisio, PhD; Steven Duffy, PgD; Adrian V. Hernandez, MD, PhD; J. Christiaan Keurentjes, MD, PhD; Shona Lang, PhD; Kate Misso, MSc; Steve Ryder, MSc; Simone Schmidlkofer, MSc; Marie Westwood, PhD; Jos Kleijnen, MD, PhD.  Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA 2015; 313 (24): 2456-2473.  Abstract.


Thomas JA, Tubaro A, Barber N, Thorpe A, Armstrong N, Bachmann A, et al. The continuing story of the cost-effectiveness of photoselective vaporization of the prostate versus transuretheral resection of the prostate for the treatment of symptomatic benign prostatic obstruction. Value in Health 2015;18(4):376-86. Full text.


Korobelnik JF, Kleijnen J, Lang SH, Birnie R, Leadley RM, Misso K, et al. Systematic review and mixed treatment comparison of intravitreal aflibercept with other therapies for diabetic macular edema (DME). BMC Ophthalmology 2015;15(1):52. [Epub ahead of print]. Provisional abstract (and link to full paper).


Meerpohl JJ, Schell LK, Bassler D, Gallus S, Kleijnen J, Kulig M, et al. Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN (Overcome failure to Publish nEgative fiNdings) project based on an international consensus meeting. BMJ Open 2015;5(5):e006666. Full paper.


Hollingworth W, Rooshenas L, Busby J, Hine CE, Badrinath P, Whiting PF, Moore THM, Owen-Smith A, Sterne JAC, Jones HE, Beynon C, Donovan JL. Using clinical practice variations as a method for commissioners and clinicians to identify and prioritise opportunities for disinvestment in health care: a cross-sectional study, systematic reviews and qualitative study. Health Services and Delivery Research 2015;3(13).  Full paper.


Iorio A, Spencer FA, Falavigna M, Alba C, Lang E, Burnand B, McGinn T, Hayden J, Williams K, Shea B, Wolff R, Kujpers T, Perel P, Vandvik PO, Glasziou P, Schunemann H, Guyatt G. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ 2015;350:h870. Full paper.


Fässler M, Meissner K, Kleijnen J, Hróbjartsson A, Linde K. A systematic review found no consistent difference in effect between more and less intensive placebo interventions. J Clin Epidemiol 2015;68(4):442-51. Abstract.


Worthy G. Statistical analysis and reporting: common errors found during peer review and how to avoid them. Swiss Medical Weekly 2015;145:w14076.  Full paper.