Kleijnen Systematic Reviews Ltd has been declared a "Centre of excellence" for TARs by the National Institute for Health Research (NIHR). 

Three new centres of expertise in Technology Assessment Reviews (TARs) join seven existing NIHR TAR centres. TARs provide a reliable and rigorous evidence assessment of the benefits, harms and costs of particular healthcare treatments for those who plan, provide or receive care in the NHS.

TARs are commissioned to meet the urgent needs of national NHS decision-making bodies and policy customers, such as the National Institute for Health and Clinical Excellence (NICE). TARs are most commonly produced to inform NICE Appraisal Committee guidance on the use of new and existing medicines, treatments and procedures within the NHS in England and Wales. http://www.hta.ac.uk/news/newsitem180110.shtml

We now have moved to our new office at Escrick Business Park

Jos Kleijnen and Phil Hill of S Harrison Development Ltd shake hands on the sale.

New book about systematic reviews published (in German language):  http://www.verlag-hanshuber.com/vkat/einzeltitel.php?isbn=978-3-456-84691-0


2009 Publications


Schmucker C, Grosselfinge R, Riemsma RP, Antes G, Lange, S, Lagreze W, Kleijnen J.

Diagnostic accuracy of vision screening tests for the detection of amblyopia and its risk factors: A Systematic Review.

Graefes Arch Clin Exp Ophthalmology.  11 August 2009. [Epub ahead of

print].                        


Tsourapas A, Roberts TE, Barton P, Honest H, Forbes C, Hyde C, Khan KS.
An economic evaluation of alternative test-intervention strategies to prevent spontaneous pre-term birth in singleton pregnancies.                                            Acta Obstetricia et Gynecologica Scandinavica. In press August 2009

Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
Journal of Clinical Epidemiology. 22 July 2009. [Epub ahead of print]. 
PMID: 19631508. 


Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
Journal of Clinical Epidemiology. 22 July 2009. [Epub ahead of print].
PMID: 19631507. 


Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D.
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.
British Medical Journal. 21 July 2009. 339:B2700. DOI: 10.1136/bmj.b2700.
PMID: 19622552. 


Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group.
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
British Medical Journal. 21 July 2009. 339:B2535. DOI: 10.1136/bmj.b2535. 
PMID: 19622551. 


Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group.
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
PLoS Med. 21 July 2009. 6(7):E1000097. Epub: 21 July 2009.


Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D.
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration.
PLoS Med. 21 July 2009. 6(7):E1000100. Epub: 21 July 2009 July.


Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D.
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration.
Annals of Internal Medicine. 20 July 2009. [Epub - ahead of print].
PMID: 19622512.


Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group.
Preferred reporting items for systematic reviews and meta-anlyses: the PRISMA Statement.
Annals of Internal Medicine. 20 July 2009. [Epub – ahead of print].


Southey ER, Soares-Weiser K, Kleijnen J.
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Current Medical Research and Opinion. 17 July 2009. [Epub - ahead of print].


Schmucker C, Grosselfinger R, Riemsma RP, Antes G, Lange S, Lagreze W, Kleijnen J.
Effectiveness of screening preschool children for amblyopia: a systematic review.
BMC Ophthalmology. 16 July 2009. 9(1):3. [Epub - ahead of print].


Bausch B, Spaar A, Kleijnen J, Puhan MA.
Quality of randomised trials in chronic obstructive pulmonary disease.
European Respiratory Journal. 2 July 2009. [Epub - ahead of print]


Bekkering GE, Rutjes AWS, Vlassov VV, Aebersold DM, von Bremen K, Juni P, Kleijnen J.
The effectiveness and safety of proton radiation therapy for indications of the eye: a systematic review.
Strahlentherapie und Onkologie. 2009. 185:211-221.


Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group.
Preferred reporting items for systematic reviews and meta-anlyses: the PRISMA Statement.
Open Med. 2009. 3(2):123-130


Strassmann R, Bausch B, Spaar A, Kleijnen J, Braendli O, Puhan MA.
Smoking cessation interventions in COPD - A network meta-analysis of randomised trials.
European Respiratory Journal. 8 April 2009. 10.1183/09031936.00167708


Wolff R, Hommerich J, Riemsma RP, Antes G, Lange S, Kleijnen J.
Hearing Screening in Newborns. Systematic Review of Accuracy, Effectiveness, and Effects of Interventions after Screening.
Archives of Disease in Childhood. First Published Online : 26 March 2009. DOI:10.1136/adc.2008.151092


Kleijnen J, Bekkering GE.
Leserbriefe. Verfahrensweisen und Methoden zur Nutzenbewertung von Arzneimitteln in Deutschland. Ein Auftragsgutachten. Erwiderung.
DMW - Deutsche Medizinische Wochenschrift. 2009. 134:320.


Puhan MA, Bachmann LM, Kleijnen J, ter Riet G, Kessels AG.
Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis.
BMC Medicine. 2009. 7:2.


2008 Publications

Bekkering GE, Kleijnen J.
Verfahrensweisen und Methoden zur Nutzenbewertung von Arzneimitteln in Deutschland.
DMW - Deutsche Medizinische Wochenschrift. 2008. 133(Suppl-7):S225-S246.


Hempel S, Chambers D, Bagnall A-M, Forbes C.
Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies.
Psychological Medicine. 2008. 38(10):915-926.


Bekkering GE, Kleijnen J.
Procedures and methods of benefit assessments for medicines in Germany.
European Journal of Health Economics. 2008. 9(Suppl 1):S5-S29.


Bala MM, Riemsma RP, Nixon J, Kleijnen J.
Systematic review of the (cost-)effectiveness of spinal cord stimulation for people with failed back surgery syndrome.
Clinical Journal of Pain. 2008. 24:741–756


El-Mansoury TM, Taal E, Abdel-Nasser AM, Riemsma RP, Mahfouz R, Mahmoud JA, El-Badawy SA, Rasker JJ.
Loneliness among women with rheumatoid arthritis: a cross-cultural study in the Netherlands and Egypt.
Clinical Rheumatology. 2008. 27(9):1109-1118.


Bagnall AM, Jones L, Duffy S, Riemsma RP.
Spinal fixation surgery for acute traumatic spinal cord injury.
Cochrane Database of Systematic Reviews. 2008. (1):CD004725.


Morris RK, Cnossen JS, Langejans M, Robson SC, Kleijnen J, Ter Riet G, Mol BW, van der Post JA, Khan KS.
Serum screening with Down's Syndrome markers to predict pre-eclampsia and small for gestational age: Systematic review and meta-analysis.
BMC Pregnancy Childbirth. 4 August 2008. 8(1):33.


Cnossen JS, Morris RK, ter Riet G, Mol BWJ, van der Post JAM, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJE, Kleijnen J, Khan KS.
Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis.
CMAJ. 2008. 178(6):701-711.


2007 Publications


Bekkering GE, Abou-Setta AM, Kleijnen J.
The application of quantitative methods for identifying and exploring bias in systematic reviews: PDE-5 inhibitors for erectile dysfunction.
International Journal of Impotence Research. 6 December 2007. [Epub - ahead of print].


Burch JA, Soares-Weiser K, St John DJ, Duffy S, Smith S, Kleijnen J, Westwood M.
Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review.
Journal of Medical Screening. 2007. 14(3):132-137.


Collins R, Burch J, Cranny G, Aguiar-Ibanez R, Craig D, Wright K, Berry E, Gough M, Kleijnen J, Westwood M.
Duplex ultrasound, magnetic resonance angiography, and computed tomography angiography for the diagnosis and assessment of symptomatic, lower limb peripheral arterial disease: systematic review.
British Medical Journal. 16 June 2007. 334(7606):1257-1261.


Morris RK, Khan KS, Coomarasamy A, Robson SC, Kleijnen J.
The value of predicting restriction of fetal growth and compromise of its wellbeing: Systematic quantitative overviews (meta-analysis) of test accuracy literature.
BMC Pregnancy Childbirth. 8 March 2007. 7:3.


Collins R, Fenwick E, Trowman R, Perard R, Norman G, Light K, Birtle A, Palmer S, Riemsma RP. A systematic review and economic model of the clinical effectiveness and cost-effectiveness of docetaxel in combination with prednisone or prednisolone for the treatment of hormone-refractory metastatic prostate cancer.
Health Technology Assessment. January 2007. 11(2).


Bagnall A, Fenton M, Kleijnen J, Lewis R.
Molindone for schizophrenia and severe mental illness.
Cochrane Database of Systematic Reviews. 24 January 2007. (1):CD002083.


Crawford F, Inkster M, Kleijnen J, Fahey T.
Predicting foot ulcers in patients with diabetes: a systematic review and meta-analysis.
Q J Med. 2007. 100:65-86.


Lucas P, Arai L, Baird J, Kleijnen J, Law C, Roberts H.
A systematic review of lay views about infant size and growth.
Archives of Disease in Childhood. 2007. 92:120-127.